Talk:Quinine

This is the talk page for discussing improvements to the Quinine article.
This is not a forum for general discussion of the article's subject.

Put new text under old text. Click here to start a new topic.
New to Wikipedia? Welcome! Learn to edit; get help.

Article policies

Find medical sources: Source guidelines · PubMed · Cochrane · DOAJ · Gale · OpenMD · ScienceDirect · Springer · Trip · Wiley · TWL

Archives: Index, 1: 90 days

Ideal sources for Wikipedia's health content are defined in the guideline Wikipedia:Identifying reliable sources (medicine) and are typically review articles. Here are links to possibly useful sources of information about Quinine.

PubMed provides review articles from the past five years (limit to free review articles)
The TRIP database provides clinical publications about evidence-based medicine.
Other potential sources include: Centre for Reviews and Dissemination and CDC

Food and drink Mid‑importance

Food portal

This article is within the scope of WikiProject Food and drink, a collaborative effort to improve the coverage of food and drink related articles on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.Food and drinkWikipedia:WikiProject Food and drinkTemplate:WikiProject Food and drinkFood and drink articles

Mid

This article has been rated as Mid-importance on the project's importance scale.

Food and Drink task list:

To edit this page, select here

Here are some tasks you can do for WikiProject Food and drink:

Help bring these Top Importance articles currently B Status or below up to GA status: Agaricus bisporus (i.e. mushroom), Beef, Bread, Curry, Drink, Food, Ham and eggs, Soy sauce, Sushi, Yogurt
Bring these Top Importance articles currently at GA status up to FA status: Beer, French cuisine, Sugar
Bring these High Importance articles currently at GA status up to FA status: Apple, Burger King, Fish
Participate in project-related deletion discussions.
Delete unrelated trivia sections found in articles. Please review WP:Trivia and WP:Handling trivia to learn how to do this.
Add the {{WikiProject Food and drink}} project banner to food and drink related articles and content to help bring them to the attention of members. For a complete list of banners for WikiProject Food and drink and its child projects, select here.
Provide photographs and images for Category:Wikipedia requested images of food
Consider joining this project's Assessment task force. List any project ideas in this section

Note: These lists are transcluded from the project's tasks pages.

Pharmacology Mid‑importance

	This article is within the scope of WikiProject Pharmacology, a collaborative effort to improve the coverage of Pharmacology on Wikipedia. If you would like to participate, please visit the project page, where you can join the discussion and see a list of open tasks.PharmacologyWikipedia:WikiProject PharmacologyTemplate:WikiProject Pharmacologypharmacology articles
Mid	This article has been rated as Mid-importance on the project's importance scale.

Medicine Mid‑importance

	Medicine portal This article is within the scope of WikiProject Medicine, which recommends that medicine-related articles follow the Manual of Style for medicine-related articles and that biomedical information in any article use high-quality medical sources. Please visit the project page for details or ask questions at Wikipedia talk:WikiProject Medicine.MedicineWikipedia:WikiProject MedicineTemplate:WikiProject Medicinemedicine articles
Mid	This article has been rated as Mid-importance on the project's importance scale.

Chemicals Mid‑importance

	This article is within the scope of WikiProject Chemicals, a daughter project of WikiProject Chemistry, which aims to improve Wikipedia's coverage of chemicals. To participate, help improve this article or visit the project page for details on the project.ChemicalsWikipedia:WikiProject ChemicalsTemplate:WikiProject Chemicalschemicals articles
Mid	This article has been rated as Mid-importance on the project's importance scale.

vs quinidine

There is a "do not confuse" flag in both quinine and quinidine, but they appear (in the chemical formula and skeletal diagram, as well as the listed characteistics like molecular weight) to be identical. Are they merely two different medical uses of the same compound, or are they chemically different in some (unspecified in the article or data page) way? Riventree (talk) 12:25, 10 April 2017 (UTC)[reply]

Very similar they are.[1] They are isomers but not enantiomers. Doc James (talk · contribs · email) 18:12, 10 April 2017 (UTC)[reply]

The skeletal diagrams are different. If you look at the wedge-shaped connectors for each of -OH and -H in the middle of the molecule, you will see that in quinine they are solid and in quinidine the same two are dashed. That is not just as style thing - solid wedges means the bond points up out of the plane of the page, and the dashed wedge means the bond points down. See [[2]]. Those differences give the molecules different activities Jytdog (talk) 18:33, 10 April 2017 (UTC)[reply]

Contraindications

Under the "Contraindications" heading, the second to last sentence says "In people with atrial fibrillation, conduction defects, or heart block, quinine can cause heart arrhythmias, and should be avoided.[30]". The reference leads one to a study titled (which can bee seen in the references section of the article) "Off-label use of sildenafil in valvular heart disease should be avoided". So, the reference providing evidence that quinine "can cause heart arrhythmias, and should be avoided" actually refers to sildenafil. I'm no medical expert, but the reference should refer to the drug in question, quinine, and not another (sildenafil). — Preceding unsigned comment added by 73.42.197.25 (talk) 06:03, 29 May 2020 (UTC)[reply]

Traditional Use

Under History, there was a statement that: Quinine was used ... to halt shivering "due to low temperatures." This sounds rather stupid to me... shivering is feared when it is due to fever, not just "due to low temperatures" where intuitively it could be dangerous to suppress it. So I searched the citation given (which was interesting: https://books.google.com/books?id=ATQbAAAAYAAJ&pg=PA302#v=onepage&q&f=false), but I found no references at all to "shivering" or anything about low temperatures... I think some contributor may have just made this up naively thinking it was a "logical" explanation. Anyhow, I removed "due to low temperatures" unless it can be supported with a direct quote. It would still be nice to make the entire part about traditional use a bit more precise with citations pointing to the **exact** passages that support each claim. DKEdwards (talk) 19:23, 4 October 2020 (UTC)[reply]

World War II

In the article, it is stated "Tens of thousands of US troops in Africa and the South Pacific died of malaria due to the lack of quinine." While I don't have access to the book, I am unable to find any numbers backing up this fact and the number itself seems quite implausible. From https://history.stackexchange.com/questions/58525/what-was-the-estimated-malaria-death-toll-for-us-forces-during-world-war-ii , the fatality number looks closer to 100, than "tens of thousands", which would make malaria one of the leading causes of death in WWII. 2601:645:8200:61E0:31FF:79D8:983D:A4EC (talk)

Error in chemical structure of secologanin

The diagram of the biosynthesis of quinine has an incorrect structure of secologanin. The tetrahydropyran ring (six membered ring with five carbons and one oxygen), has a (correct) pendant vinyl group [pyran]-CH=CH2 and an incorrect pendant allyl group [pyran]-CH2-CH=CH2. The allyl group should actually be an acetaldehyde group, [pyran]-CH2-CH=O. I.e., change the terminal =CH2 group to an =O atom. AdderUser (talk) 06:22, 12 December 2021 (UTC)[reply]